Instead of 'predictions' this is going to be a 'wishlist' because predictions normally mean that you have some kind of information all I have is what I have read, and because of that I'll just list what I'd love to see from what I know might happen. While I try to not be biased, I am quite invested in Sony's Playstation 3. I am also highly considering getting an Xbox360 mainly for Valve's games. So I'll be concentrating on those two consoles for this wishlist of things I'd like to see in this year's E3. While Nintendo's sales are still strong, there is
absolutely nothing
they can do to get my money right now, so I'll mention them at the end... if I remember to.
Sony
Few things that I don't expect at all but would be killer announcements:
Microsoft
Nintendo